What causes gout - Scientists discover
3 genes are associated with gout
What causes gout, an extremely painful form of arthritis that affects an estimated 2 to 5 million Americans? In September 2008, researchers published study findings showing that the presence of three genes can raise the risk for gout by as much as 40 times.
The study, published in Lancet, identified two new genes and confirmed the role of a third gene that are associated with an increased risk for developing gout. Scientists say that this discovery may lead to testing that can allow doctors to assess a person's risk for gout before the appearance of any symptoms.
This research project involved analyzing data collected in two large studies, the Framingham Heart Study with 7,700 participants and a Netherlands Rotterdam Study with 4,100 participants. Results then were replicated using data from another massive study with 14,900 participants, called the Atherosclerosis Risk in Communities Study.
Want to know which foods contribute to developing gout? See our page on research linking specific food groups to gout.
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